Serie A Matchday 4 – Matches, Rivalries and Predictions

Like every other major league in football, the Serie A 2025-26 season brings the pure joy of football fanaticism. Matchday three ended successfully last week, leaving fans on a rollercoaster ride of hope and despair. Notably, teams like Juventus and Atalanta were on a scoring spree. Scoring above 3, these teams led the week’s headlines. Now, the eyes turn towards matchday 4. The rivalries were fresh off the table for the fourth matchday. For this reason, fans are completely wondering what will take place. Strikingly, the rivals like Inter Milan vs Sassuolo and Torino vs Atalanta create huge expectations among fans. Additionally, narratives like European tournament qualifications, relegations, and promotions intensify the match even more. This preview will give you a detailed breakdown of teams, head-to-head records, and predictions for the upcoming matchday 4. Let’s look at them one by one. Click here to get more Serie A updates.

Serie A 2025 Matchday 3 – Highlights

Matchday 3 was unrestrained in giving out surprises and disappointments. What fans had expected was utterly shattered. For instance, an elite club like Inter Milan might be expected to take down every team they face. However, they lost it to Juventus’s squad by a single goal. Mostly, teams won by scoring only one goal throughout the match, including two draws. This shows us how tight the matches were at matchday 3. Let’s look at some of the highlights. If you are interested in more of our football news, click here.

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As we said, most of the matches were held tightly, with only one scoreboard. Four clean sheets were recorded, yet all came with a single-score win. Additionally, there were two draws, 0-0 and 1-1. The match between Roma and Torino was so close that both teams mostly lingered on retaining the ball. Only in the 59^th minute did Torino have its luck, registering a score and winning the fixture narrowly. Como vs Genoa was another such close encounter, where Como took the lead in the 13th minute initially. After that, Como and Genoa started to increase their midfield play. This lasted until the very end, where Genoa scored in the 90+2 minute. That goal tied the match after a nail-biting showdown. Another such draw came from Verona vs Cremonese. Neither scored a single goal, focusing on being more defensive rather than scoring proactively.

Notable Victories

The week’s highlight, Juventus vs Inter Milan, was unpredictable and tense until the last minutes. This clash between Juventus and Inter Milan almost ended up getting tied, where everyone thought it would be a draw. By the 90^th minute, both teams had scored three goals. Both teams were firmly determined not to concede a single more goal at that time. However, to everyone’s surprise, Vasilije Adžić scored the final decisive goal for Juventus in the 90+1 minute. This end was a cathartic relief for Juventus fans that day. Sassuolo had a similar matchup with uncertainty. They scored the crucial one goal after not scoring at all. Throughout the match, Sassuolo focused more on midfield defense and ball possession. But their passes and shot-making were nullified. This was the same case for their opponent, Lazio. However, at the 70^th minute, Sassuolo’s Alieu Fadera scored a goal and earned the lead. 

Standout Performances

Charles De Ketelaere astonished the fans with his two goals, which are furthermore crucial for Atalanta. After Giorgio Scalvini’s starting goal, Charles De Ketelaere added another goal in the 51^st minute. Successively, he scored one more goal in the 73rd minute, creating a solid score sheet to manage effortlessly. Just like him, Hakan Çalhanoğlu of Inter Milan rushed onto the ground and bagged two goals despite the team’s loss. These are some of the best individual performances that took place in the match on day 3. Let’s hope for a similar matchup in the upcoming Matchday 4. Need more sports news? Follow Bettingpremier.

What’s Ahead in the Serie A 2025-26 Matchday 4

Lecce vs Cagliari

In the upcoming Serie A 2025-26, U.S. Lecce will face Cagliari Calcio on September 19, 2025. This clash will occur at Stadio Via del Mare at 02:45 p.m. ET.

Prediction

Lecce has always been a reactive force that tries more on the defensive front and scores sparsely. They have won about five of their last ten matches, with three losses and two draws. Most of their wins came from a single-goal difference. This highlights their weakness as being vulnerable to aggressive teams. Lecca might collapse to defend and helplessly concede if their opponent shows more attacking force. Concisely, Lecce has a decent form that will find its way to break Cagliari. Conversely, Cagliari’s squad has been a bit lethargic lately. They have won only four matches, with three draws and three losses in their last ten games. Historically, Lecce has dominated Cagliari in the head-to-head encounters. Additionally, Lecce gets a home advantage in this Serie A matchup. Lecce is especially good at home. Hence, Lecce can take down Cagliari in this Serie A match.

Bologna vs Genoa

Bologna F.C. 1909 hosts Genoa C.F.C. on 20 September 2025 at 09:00 a.m. ET at the historic Renato Dall’Ara Stadium. The home side will leverage its form, while Genoa seeks consistency in this Serie A clash.

Prediction

Bologna’s current form looks promising, especially at home. In their recent matches, Bologna scored an average of 2.4 goals per game. They are also decent on the defensive side, giving them a rounded profile. Notably, their offense gets unleashed at home matches despite their occasional falls at home. To talk about the head-to-head encounter, Bologna and Genoa fought most recently in May 2025. Genoa captured Bologna at home by 3-1. Although this may raise questions about Bologna’s efficiency, Genoa’s consistency is a concern. Genoa has declined over the last ten matches due to inconsistent home and away form. Their offense is not satisfying enough to break Bologna’s tactical prowess. However, Genoa boasts a recent home win against Mantova. This match will be a tight contest with both sides’ strengths and weaknesses. Yet, Bologna’s superior current form will take down Genoa in this Serie A clash.

Verona vs Juventus

Verona takes on Juventus on 20 September 2025, at 12:00 p.m. ET at the Stadio Marcantonio Bentegodi. Juventus will aim to extend their strong start to the season against a tough Verona side at home.

Prediction

Juventus F.C. always had the upper hand against Hellas Verona. They have a strong head-to-head record against Hellas Verona in Serie A. Out of 65 clashes, Juventus has won 37 of them. Even in the last four matches, Juventus had a clean sheet win against Verona. This includes a 2-0 home win and a 3-0 away win. Without conceding goals against Verona, Juventus flexes its dominance in the field. In addition, Juventus has a strong defensive front, especially at home. On the other side, Verona has issues with attacking and progression. Their defense also lacks structure and cohesion, having conceded many goals. Above all, Juventus’s recent tactical reforms bring new considerations. Juventus has implemented a new formation of a back three from the traditional back four. Consequently, their defense will become more solid. Hence, we can conclude that Juventus will beat Verona on the Serie A matchday 4.

Udinese vs Milan

The action continues with Udinese vs. Milan scheduled for 20 September 2025, at 02:45 p.m. ET at the Bluenergy Stadium. Milan travels for this afternoon’s clash to assert dominance over a resilient Udinese team.

Prediction

As we observed, Udinese Calcio has been in great form recently. They have opened the season with 2 wins and a draw, placing them 4^th in the Serie A 2025-26 table. Their strong form has shown scoring 8 goals in the last 5 matches and boasts an undefeated streak. Keinan Davis manages the team’s attacking side singlehandedly. Similarly, AC Milan has shown decent form, scoring seven goals in the last five matches. They sit fifth, right below Udinese, in the Serie A rankings. But Milan dominates in the head-to-head records, having won 22 games against Udinese’s 15. Interestingly, they have kept more clean sheets in the competition. Tactically, Udinese has a compact defense that employs a deep defensive line. It primarily focuses on controlling the midfield and building through the thirds. However, Milan statistically and historically outperforms Udinese. Hence, A.C. Milan will win in this matchup.

Lazio vs Roma

The Rome derby between Lazio and Roma is set for 21 September 2025 at 06:30 a.m. ET at Stadio Olimpico. This Serie A rivalry promises high intensity and could significantly impact both clubs’ campaigns.

Prediction

S.S. Lazio has been inconsistent in recent matches, with two losses in their last three against Roma. We can clearly see them struggling to convert possession into goals in the previous matches. They also have discipline issues and receive frequent yellow cards. On the other hand, A.S. Roma secured a reasonable draw 1-1 against Juventus in their last outing. They have a stunning 70% winning ratio in their previous 10 matches. Roma intimidates with its frequent clean sheet victories, which show their defensive strength. Overall, Roma shows a good current form and overall record against Lazio. This time, Lazio gets the home advantage; they perform well at home matches. Both teams favor a 4-3-3-1 formation, which could lead to a significant midfield battle. This Serie A encounter is expected to be a closely contested match. However, Roma is the clear favorite to win due to its current form.

Torino vs Atalanta

Torino F.C. welcomes Atalanta B.C. on 21 September 2025, at 09:00 a.m. ET at Olimpico di Torino. Both teams are pushing for European qualification and will see this as a pivotal early-season encounter.

Prediction

Torino has been inconsistent, losing a substantial number of fixtures lately. However, they are known for their unbeatable status at home, having drawn more European league matches there. Meanwhile, Atalanta appears to be in good away form and is expected to secure a comfortable win. Historically, Atalanta has a slightly better head-to-head record against Torino, winning 16 matches to Torino’s 15, with 17 draws. Atalanta has a more consistent record in offense, often scoring even in matches they lose. Conversely, Torino is struggling to score a goal, often losing goalless. Tactically, Torino will likely implement a 3-4-2-1 formation, giving them defensive solidity and pressing. Atalanta also prefers the same 3-4-2-1 formation, making the duel more of a hand-to-hand combat. Although Torino had great physicality, Atalanta’s quick transitions will outperform Torino. Therefore, this Serie A clash will lean towards Atalanta’s favor despite being a tight contest.

Cremonese vs Parma

U.S. Cremonese vs. Parma Calcio 1913 will kick off at 09:00 a.m. ET on 21 September 2025. This fixture offers a heated regional battle as both sides fight at the Stadio Giovanni Zini

Prediction

Cremonese is riding its newfound momentum after being promoted to Serie A and having a strong early-season start. In contrast, Parma has had a tough start to the current Serie A campaign. Given both teams’ dynamics, this match will be unpredictable and hard-fought. Cremonese got the psychological boost after getting Serie A participation after a two-season absence. By winning the first two league rounds, Cremonese shows solid form. Conversely, Parma is struggling with a poor start to the season, with one draw and one loss. In the last six meetings, Cremonese has won three, Parma has won two, and one draw. Although the difference is not so great, Cremonese’s emerging form has the advantage of winning over Parma.

Fiorentina vs Como

ACF Fiorentina hosts Como 1907 on 21 September 2025, at 12:00 p.m. ET at the Stadio Artemio Franchi. The Fiorentina will be eager to protect their home turf against newly promoted Como, who have already shown promise.

Prediction

Como appears to be in better overall form than Fiorentina, given their current 2025 Serie A standings. They have a 60% winning ratio with an ironic form where they perform better away than at home. Mostly, they won the match by keeping a clean sheet. In their recent matches, they have shown an intimidating defense. The way they break down progression and avoid getting conceded tells about their defensive tactics. On the other hand, Fiorentina looks frail in both defense and offense. Although they show occasional performance bursts, they fail to deliver them consistently. With frequent goalless losses, Fiorentina falls prey to Como’s aggressive attack. In this Serie A clash, Como will beat Fiorentina easily.

Inter Milan vs Sassuolo

F.C. Internazionale Milano faces U.S. Sassuolo Calcio on 21 September 2025, at 02:45 p.m. ET at San Siro. With Inter aiming to stay in title contention, Sassuolo arrives as a potential upset threat.

Prediction

Inter Milan is a strong Italian football club with an elite level of international experience. It is currently ranked 11th in Serie A 2025-26. With a 60% winning ratio, Inter Milan is reigning with a threatening form and strengths. They have an average of 2.1 goals per match, which is already above average. As for their defense, they have a decent amount of clean sheet wins, conceding fewer goals. Sassuolo, on the other hand, is irregular in their recent matches. They often draw the match or lose without scoring goals. Sassuolo does not seem to have a proper and consistent form at home and away. Their offense has been pretty underwhelming for the last ten matches, averaging around 0.9 goals per game. Besides these, Inter Milan gets the home advantage with a good home record. As a result, Inter Milan will surely win in this upcoming Serie A matchup.

Napoli vs Pisa

Matchday 4 wraps up with Napoli vs Pisa on 22 September 2025, at 02:45 p.m. ET. This Serie A clash will happen at the Stadio Diego Armando Maradona.

Prediction

S.S.C. Napoli leads the Serie A Rankings with 9 points as of 16 September 2025. They have a 70% winning ratio and can turn potential losses into draws. For their last 10 matches, Napoli has scored 1.9 goals per game and never conceded much. Offensively, the team is consistent in scoring, especially at home matches. Under Antonio Conte’s management, the squad includes high-profile players like Kevin De Bruyne, Scott McTominay, and Romelu Lukaku. Currently, they are the defending champions, having won the 2024-25 title. In a great contrast, Pisa stands hopeless amid a powerhouse like Napoli. With not-so-consistent records and frequent losses, Pisa has a weak overall form. Compared with Napoli’s superior form, Pisa’s underwhelming squad will become vulnerable. Therefore, Napoli will undoubtedly beat Pisa S.C. in this Serie A clash.