NFL 2025-26 Week 10: American Football Predictions

Welcome to NFL Week 10, where touchdowns and interceptions are even more tense than ever before. The losers still have a chance at Super Bowl contention, while the table’s leading teams think it’s pointless. We have some of the most-awaited rivalries awaiting in Week 10. Being one of the league’s top teams, the Colts are preparing to face the Falcons. Buccaneers vs Patriots is another clash that excites fans. Besides these, 49ers vs Rams, Packers vs Eagles, and Chargers vs Steelers are other classes that ignite a furious rivalry. Looking at the table, the Broncos, Colts, Patriots, and the Bills are performing at an excellent pace with consistency. However, the standings can fluctuate at any given moment depending on the upcoming games. So, there won’t be a single game that leaves you bored. To get more updates on the ongoing American football events, keep in touch with Bettingpremier.

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NFL Week 9 Highlights – Notable Moments

The National Football League is bringing the Week 10 fixtures with thrilling clashes in the list. Last week was tremendously entertaining, with the Bears scoring the week’s highest score. The Steelers’ win over the league’s best Indianapolis squad was the talk of the town. Similarly, the New England Patriots shutting down the Falcons with a dominant early quarter was entertaining. The Ravens gave the Dolphins a taste of their own medicine. They continuously scored four touchdowns and follow-up conversions. At the same time, the Dolphins had enough luck only to score two field goals. Similarly, the 49ers’ additional touchdown conversion and a field goal earned them a ten-point lead. These were some of the best moments in NHL Week 9. Now heading towards Week 10, we have given match previews for some crucial clashes. Let’s look at them below. Click here to get regular NFL updates like this.

Expectations Ahead of NFL Week 10

Currently, the Broncos are managing the team without their star players on the roster. However, the young players seem to do well as they are more frequent in touchdowns and field goals. So, the young players’ game will be hugely expected in the clash against the Raiders. The Colts, on the other hand, show up with their declining offensive line. It was so out of the blue for the fans to witness the Colts’ defeat on Sunday. However, this time, the QB Daniel Jones’ performance will be changed, given the offensive line’s irregularities. Similarly, the New England Patriots’ QB had a reflection on his past performances. Despite a dominant record, QB Drake Maye had numerous hits. He said that he must play better after being affected by turnovers twice. In short, teams will reflect on their past games in this NFL Week 10. Keep getting more sports news here.

NFL Predictions for Week 10

Ready to pick the winning side? Get guided by our technical preview and NFL picks for each matchup below.

Broncos vs Raiders

The Denver Broncos and the Las Vegas Raiders will face off in the upcoming NFL clash. This game begins at Empower Field at 08:15 p.m. ET on November 06, 2025.

Denver Broncos

The Denver Broncos’ defense is one of the league’s best. They show a resilient and strong defensive side, threatening their opponents’ run game. Throughout this season, they have allowed only a low number of chances to their opponents. It places them in a good spot in overall defense. Patrick Surtain II’s absence might hinder their defensive drive. But they look just fine, as they did in their previous game. However, Brock Bowers is a heavy offensive threat whose run game is strong. Considering the scoring chances, the Raiders have allowed more opportunities, indicating a positive sign for Denver’s run game.

Las Vegas Raiders

The Las Vegas Raiders are currently in a below-average state with two wins and six defeats. Their weak defense is the main reason, as they allow many scores each time they lose. However, their offense showed an improvement in recent games. While still having a developing offense, the team traded Jakobi Meyers. It leaves the quarterback helpless on the offensive line despite having a replacement. The Denver Broncos’ defense is tight and has a better ranking. Hence, the Raiders will have issues scoring on the road.

Prediction

The Denver Broncos will pierce the Raiders’ depleted defense and outscore them in this NFL game.

Colts vs Falcons

Ready for the next game as the Indianapolis Colts welcome the Atlanta Falcons to Olympiastadion. The game starts at 09:30 a.m. ET on November 09, 2025.

Indianapolis Colts

The Indianapolis Colts recently fell at the Pittsburgh Steelers’ hands. They had numerous turnovers and gradually lost momentum. Their offense couldn’t help but slow down against the Steelers’ defense. However, the quarterback’s presence brought two touchdowns despite the loss. Given it’s an away loss, their ability to come close remains a key factor. Moreover, the Indianapolis Colts remain the top team in the league with a dominant record.

Atlanta Falcons

On the other hand, the Atlanta Falcons’ Zac Robinson has faced numerous criticisms of his apparent offensive strategies. The team’s offense has been underwhelming for the past three games. Quarterback Kirk Cousins’s efficiency is a concern that we should look at. Michael Penix Jr.’s return remains crucial as he brought three touchdowns with a partially powered offensive line. Previously, they performed at an excellent pace, coming close to the Patriots on the road. However, their conversions fell short in the final quarter after the third touchdown. But playing away, the Falcons will face defensive struggles given the Colts’ home form.

Prediction

The Indianapolis Colts have the winning chance at home.

Buccaneers vs Patriots

The Tampa Bay Buccaneers are ready to face the New England Patriots on November 09, 2025. This NFL game begins at 01:00 p.m. ET at Raymond James Stadium.

Tampa Bay Buccaneers

The Tampa Bay Buccaneers stand close to the New England Patriots in the league standings. They have a 6-2 record with a good offensive form at home. But they lost twice recently, a home and an away fixture. They need to prepare to face the Patriots’ powerhouse Drake Maye. He continues to stack up touchdowns and keeps adding more scoring potential. The team arrives with a recent dominant victory, where they swept the Saints by allowing only a single field goal. Collectively, the Tampa Bay Buccaneers have performed very well, particularly at home, despite some minor shortcomings.

New England Patriots

The New England Patriots have no problems visiting teams on the road. They have a winning record and a solid offensive side. With a  7-2 record, the Patriots currently rank third in the league. Drake Maye has scored over 17 touchdowns in nine games played so far. His scoring potential is indeed a considerable threat to the Buccaneers. They have won in four of their last five games. Under Mike Vrabel, the Patriots are performing great, to everyone’s surprise. Above all, they have a strong defense ranked first in the league. But they have shown some minor vulnerabilities in the red zone.

Prediction

This game will be close, given both sides’ dominant league records. But given New England’s unmatched potential, they will upset the hosts in this NFL clash.

Dolphins vs Bills

Be ready for the upcoming Dolphins vs Bills matchup at Hard Rock Stadium. The NFL game will kick off at 01:00 p.m. ET on November 09, 2025.

Miami Dolphins

The Dolphins enter with a struggling season record of two wins and seven losses. This landed them at the AFC’s bottom, leaving them hopeless. Quarterback Tua Tagovailoa’s contribution remains solid as usual. However, the team’s overall performance is concerning. Concisely, the Dolphins’ current form indicates a difficult upcoming match despite a home advantage. Playing against the divisional rivals, the Dolphins are expected to struggle to contain the Bills.

Buffalo Bills

The Buffalo Bills had a decent start to the season and sustained the momentum until now. Currently with a 6-2 record, they are at the league’s top. Quarterback Josh Allen’s remarkable performance delivers consistent touchdowns throughout the games. Running back James Cook also adds further strength to the team’s offense. Their defense is also strong, as they recently pressured the Chiefs’ containing of Patrick Mahomes.

Prediction

The Bills appear to be in great form recently. Therefore, we can expect the Buffalo Bills to capture this away fixture.

Texans vs Jaguars

The Jacksonville Jaguars will visit the Houston Texans in the upcoming NFL game on November 09, 2025. This game will start at 01:00 p.m. ET at NRG Stadium.

Houston Texans

The Texans’ game has been inconsistent with irregular results. Their record shows poor current form this season. They recently had a defeat to the Broncos 15-18 with a weak offense. But their defense is good, with numerous touchdowns and interceptions. However, their irregular form makes it a critical home match against a divisional rival. In addition, the turnover rates are high enough to indicate a weak offensive side.

Jacksonville Jaguars

Given their poor records, the Jaguars are in the same boat as the Texans. They suffered a commanding defeat at the hands of the Rams and a recent win over the Raiders. Notably, Cam Little set the record for the all-time highest field goal. He kicked the 68-yard field goal, earning the win. However, their offensive line struggles are real. A key defensive player, Travon Walker, went out for throwing a punch. Their pass rush is also inconsistent, evoking questions about their run game.

Prediction

The Houston Texans have the winning probability at home.

Seahawks vs Cardinals

The Arizona Cardinals will visit the Seattle Seahawks at Lumen Field on November 09, 2025. This NFL game will start at 04:05 p.m. ET.

Seattle Seahawks

The Seattle Seahawks lead the AFC West with a perfect record. They recently beat the Commanders 38-14. Quarterback Sam Darnold’s 330-yard rushing and four touchdowns prove his standalone offensive strength. It shows their ability to dominate teams in aerial play. Jaxon Smith is another key strength that further strengthens the team’s attacking side. Under Mike Macdonald’s coaching, the Seahawks hold a 6-2 record in the league. 

Arizona Cardinals

The Arizona Cardinals arrive with a relatively poor league record. They recently had a high-margin win against the Dallas Cowboys with a score of 27-17. The team’s main offensive strength relies on Jacoby Brissett. However, they had some commanding defeats from big teams. Although their league run is average so far, their scoring potential seems completely fine. Jacoby Brissett’s standalone performance is nearly perfect. However, the offensive line rarely delivers to his needs. After all, their key Quarterback, Kyler Murray’s participation, is uncertain with a sustained injury. This may complicate their difficulties further.

Prediction

The Seattle Seahawks are the clear favorite to win in this NFL game.

Commanders vs Lions

Watch the Detroit Lions take on the Washington Commanders on November 09, 2025. The Game will start at Northwest Stadium at 04:25 p.m. ET.

Washington Commanders

The Commanders are literally struggling to find a place in the top. With six defeats and two wins, they are currently ranked at the league’s bottom. They lost all three of their previous games by a huge margin. This indicates a poor offense both at home and on the road. Playing at home, the team can gain some momentum in the opening quarters. But their overall performance is uncertain.

Detroit Lions

The Detroit Lions squad also has an irregular record with fluctuating results. However, their overall league record is better than that of the Washington Commanders. They have won five games and lost three. Two of their defeats were the most recent ones, suggesting a lack of momentum. Playing away, the Detroit Lions have equal risks as the hosts.

Prediction

This game will be a close contest, as both teams have shown vulnerabilities. However, the Washington Commanders are more likely to win, given their home advantage.

49ers vs Rams

The 49ers will visit the Rams at Levi’s Stadium. This NFL game will begin at 04:25 p.m. ET. The clash will occur on November 09, 2025.

San Francisco 49ers

The San Francisco 49ers have the perfect divisional record. They sit right below the Rams, making this clash a fierce rivalry. If the 49ers manage to secure another win, they will push the Rams back to the third divisional spot. However, the odds are against the 49ers. They have a total of 19 touchdowns so far, which is somewhat good. However, the Rams have a higher touchdown count, making them stronger in scoring.

Los Angeles Rams

The Los Angeles Rams arrive without any obligations or setbacks. They have won six games out of eight total clashes. The Rams are also better in every defensive aspect, such as turnover rate, interceptions, and sacks. Playing away this time, the Los Angeles Rams might struggle to score. However, their overall form is superior to that of the 49ers, which makes them the favorite team to win.

Prediction

The Los Angeles Rams will have an away win in this NFL game.

Chargers vs Steelers

Get the Chargers vs Steelers clash on November 09, 2025. This NFL clash will occur at SoFi Stadium at 08:30 p.m. ET.

Los Angeles Chargers

Currently, the Quarterback Justin Herbert leads the team with his potent scoring ability. Under Jim Harbaugh’s coaching, the Chargers have shown consistent offensive production. The Chargers have one of the top passing offenses with superior individual stats. They are also elite in terms of defense. The Chargers effectively limit yardage, particularly through the air.

Pittsburgh Steelers

The Steelers have a threatening scoring potential. They have the veteran Quarterback Aaron Rodgers, who is one of the best in the league. Additionally, they have one of the best scoring offenses as they rank 12^th in the league. But they have slight issues in defense as they made a substantial number of interceptions. While this could be a concern for their away game, their rushing offense and pass defense come in handy.

Prediction

The Pittsburgh Steelers are favored to sweep the Chargers on the road.

Packers vs Eagles

The Philadelphia Eagles will face the Green Bay Packers at Lambeau Field on November 10, 2025. This NFL game will start at 08:15 p.m. ET.

Green Bay Packers

The Green Bay Packers’ offensive side has been struggling, as shown in their recent games. Their Quarterback, Jordan Love, has shown a decline in the previous game, where he failed to score a touchdown. However, the team has a good overall record in the league. But they are defensively weak as they allow a significant number of yards. With a sole dependence on home advantage, the Packers will try to contain the Eagles.

Philadelphia Eagles

The Philadelphia Eagles show up with a strong squad that perfectly balances both offense and defense. Their Quarterback, Jalen Hurts, ranks among the top in the league. He has received only one interception so far while bagging 15 touchdowns. Jalen Hurts also shows good rushing touchdown efficiency. The Eagles might have difficulty restricting the Packers when they face them away. However, the recent trade acquisitions strengthened the squad.

Prediction

The Eagles will narrowly win in this close encounter against the Packers.