2025 NFL Predictions Week 3: American Football Feast

Two weeks of the NFL craze are over. This week, we are entering NFL week 3 with both the AFC and the NFC. As both weeks have concluded, almost every team in the National Football League must have played at least once. So, we might get a short foreshadowing of each team’s fate in this NFL 2025-25 campaign. Moreover, the upcoming fixtures are promising, too. With rivalries like Bills vs Dolphins, Eagles vs Rams, and Packers vs Browns, week 3 is filled with exciting matchups. Let’s look at how the teams will perform with our exclusive predictions for the upcoming NFL week 3. But before that, let’s see how some fan-favorite teams performed in both weeks. With a brief outlook on each team’s current performance and player dynamics, you will get to know the team dynamics. If you want to know more about NFL games and fixtures, keep following Bettingpremier.

NFL Week 1 & 2 – Teams Overview So Far.

Despite winning or losing, several teams have shown consistency in both offense and defense in both weeks. The injury lists, player transfers, and previous season records majorly influence the match. However, consistency and perseverance are top qualities that keep a team on top. So, to say more about each team’s performance, let’s look at their outcomes and game breakdown. Click here to get more sports breakdowns.

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Green Bay Packers

The Green Bay Packers are currently ruling the NFL as one of the best teams in the entire league. They opened with a great impact, impressing fans with consecutive wins. Even the Defending champions are stepping back to avoid extreme pressure and play a safe game. But the Packers seem to hold the whips tight to drive the horses without rest. If they keep the spirit intact throughout the season, they could secure the top 3 spots in the NFL standings.

Buffalo Bills

The Buffalo Bills are a strong AFC contender, with two wins since this season’s opening. Despite Josh Allen’s lack of MVP contributions, the Buffalo Bills are still doing well. But their defensive decline is a little concern, which is still better than many of their rivals. Getting sacked only twice, the Buffalo Bills’ defense is still decent in comparison. In addition, their strong start to the NFL 2025-26 season with a 2-0 record has created strong momentum.

San Francisco 49ers

The 49ers did a great job in the openers against the Giants. With over 279 yards gained and a career-high triple touchdown, Mac Jones lifted the team’s offense up. Their upcoming matches linger on the uncertainty of Brock Purdy’s return. It’s proven that quarterback Jones can pull wonders; the team still desires Brock Purdy’s return. However, if Brock Purdy returns, the 49ers can easily outperform or at least get close enough to the Cardinals.

Philadelphia Eagles

The Philadelphia Eagles have firmly proved why they are the reigning champions. They established a threatening tone in the openers with back-to-back wins in both weeks. Their major strength, a strong run game, keeps them at the league’s top so far. However, Hurt’s passing game still needs perfection due to low yardage totals. Most importantly, the Eagles have sparked a controversy, which has led to contemplations on rule change. Their frequent use of Tush Push caused a backfire, especially following its prominent role in the Chiefs’ game. 

Tampa Bay Buccaneers

The Tampa Bay Buccaneers have clearly shown what it takes to be a Super Bowl contender. Baker Mayfield has given his soul for the sake of the team’s victory. Even without Goedeke, the team’s offense stunned the Texans, although the score difference is not huge. The team is okay in defense. However, on the attacking side, they need Tristan Wirfs and Chris Godwin to rise above. Did you like our American football breakdown? Click here if you want more like this.

NFL Week 3 Matches – Predictions

Bills vs Dolphins

The Buffalo Bills and the Miami Dolphins will face off in the NFL’s week 3 brawl on September 18, 2025. This clash will take place at Highmark Stadium at 08:15 p.m. ET.

Prediction

The Buffalo Bills are not frail at all. In fact, their aggressive capability is still intact two weeks into the season. Josh Allen’s squad went on to secure top spots in the league stats. The Bills’ Josh Allen has dominated the Dolphins throughout his career. They have also ranked as the league’s second-best offensive side. In addition, James Cook’s strong run game is an added strength. Similarly, the Miami Dolphins have a strong offense best suited for explosive plays. But their offensive line may become vulnerable to the Buffalo Bills’ pass rush. Moreover,  the Miami squad has also struggled to keep up defensively. This is a highly vulnerable spot that the Bills could exploit. Above all, the Bills’ home advantage is the biggest adverse factor for the Dolphins’ game this time. As a result, the Buffalo Bills are the favorite to win in this upcoming NFL Week 3 game.

Vikings vs Bengals

The Vikings vs Bengals clash will happen in the U.S. Bank Stadium on September 21, 2025. Get ready to witness this clash at 01:00 p.m. ET.

Prediction

In this NFL clash, both Minnesota Vikings and Cincinnati Bengals lack their primary quarterbacks due to injury. With star passers sidelined, Carson Wentz takes over for Minnesota, and Jake Browning starts for Cincinnati. This poses uncertainty in the outcome as both teams have to rely on backups. The Vikings average around 16.5 points per game, and the Bengals 24. But both teams struggle to shield their quarterbacks. This match hints at being a tight and close contest, given that both teams struggle. However, it’s the minor differences that pave the way for decisive outcomes. The Vikings rank much higher against the pass, coupled with their aggressive attacking game. Additionally, they have a strong home crowd and a big potential from Justin Jefferson. Therefore, we can expect Minnesota Vikings to outperform Cincinnati Bengals in this NFL clash.

Titans vs Colts

The Tennessee Titans face the Indianapolis Colts at Nissan Stadium on September 21, 2025. Enjoy this NFL match happening at 01:00 p.m. ET.

Prediction

The Colts quarterback Daniel Jones is the ultimate powerhouse for the team, being highly efficient lately. With a good start to the NFL 2025-26 season, the Colts flexes their superior offensive execution. He has a profile of throwing over 580 yards and rushing for multiple touchdowns in two games. Besides that, Jonathan Taylor’s running game has also been effective that which might exploit Titans’ struggling running defense. The Titans average at just 15.5 points per game while dealing with multiple key injuries. Moreover, their rookie QB Cam Ward has faced challenges. They might overly rely on running to limit the Colts. Ultimately, Colts’ balanced squad with combined with Titans’ concerning defense, makes Indianapolis the winner in this NFL matchup.

Commanders vs Raiders

Buckle up and enjoy the fierce battle between the Commanders and the Raiders on September 21, 2025. This NFL matchup will take place at Northwest Stadium at 01:00 p.m. ET.

Prediction

The Washington Commanders team is expected to enter with Jayden Daniels after his recovery from knee injury. Being the single most offensive balance, Jayden Daniels adds a solid strength to the team’s scoring potential. Besides Jayden, the Commanders are blessed with home advantage this time. They have a good current form at home matches, giving them a slight edge. Defensive consistency is their major strength which is expected to break Raiders’ protection issues. At the same time, if we looked at Las Vegas, we can see their scoring struggles. They threw three interceptions last week, and the running game remains ineffective. As a result, their overall offense remains weak, becoming vulnerable to Commanders. Hence, the Commanders will have an easy time breaking Las Vegas Raiders’ defense and winning them.

Eagles vs Rams

Watch the Philadelphia Eagles take on the Los Angeles Rams on September 21, 2025. This NFL clash will occur at Lincoln Financial Field at 01:00 p.m. ET.

Prediction

The Philadelphia Eagles are exceptionally good at trench play with their aggressive rushing and strong offensive line protection. Although their passing game is conventional, Jane Hurts brings a clutch-driven offense. The Rams, on the other hand, attack with a balanced offense under Sean McVay’s coaching. Stafford and Kyren Williams support the team with their separate feats this season. The Rams’ defense, missing Ahkello Witherspoon due to injury, may struggle against the Eagles’ offense. They also lack Witherspoon and linebacker Keir Thomas, which weakens their secondary. Likewise, the Eagles are missing WR starters and a safety with knee injuries. This might force them to rely on running usage heavily and short passing schemes. The Rams can challenge with Stafford’s deep passing, but the absence of key defensive players makes them inadequate. In this NFL clash, the Eagles can will gain control over the ground and will beat the Rams.

Browns vs Packers

The Browns and Packers will engage in the NFL matchup on September 21, 2025, at 01:00 p.m. ET. This match will be held at Huntington Bank Field.

Prediction

The Green Bay Packers have a balanced offense and a turnover-free game. On the other hand, Cleveland’s defense appears rigid, but its inconsistent offense will lose control over rhythm. The Packers will smartly utilize Jordan Love’s passing and Josh Jacobs’ rushing. This will allow them to sustain the possession effectively. The Cleveland Browns also have a powerful defensive front led by Myles Garrett. But their offense, led by Joe Flacco, is not satisfying enough. They rank 27^th in yards per attempt and 19^th in completion. It leads to the Packers exploiting Cleveland’s inability to convert third downs. Moreover, Green Bay’s clean decision-making reduces risk. The Packers are missing WR Jayden Reed and offensive linemen Zach Tom and Aaron Banks. But they compensate with a reliable run game. The Browns, however, get a home advantage. Yet the Packers’ superior squad depth will overpower Cleveland Browns and win this NFL clash.

Buccaneers vs Jets

The Tampa Bay Buccaneers welcome the New York Jets, facing off in the NFL match on September 21, 2025. This clash will be held at Raymond James Stadium at 01:00 p.m. ET.

Prediction

The Tampa Bay Buccaneers have a solid offensive side, ranking in the top nine in passing, rushing, and pass-blocking. In particular, quarterback Baker Mayfield is Bucs’ powerhouse, having a blazing season opener. He got a 98.6 passer rating, five passing touchdowns, and no interceptions. Wide receiver Mike Evans and rookie Emeka Egbuka are additional strengths to the offense. Notably, their run defense is stronger, allowing only 76.5 yards per game. It fortifies the team, making way for deliberate action. Conversely, for the Buccaneers, their receiving depth is not so good. Beyond Garett Wilson, the Jets’ receiving depth appears weak with no solid coverage. They also struggle with an unreliable quarterback. Starting quarterback Justin Fields is on the injury list, and Tyrod Taylor comes as a backup. Overall, their current form is too fragile for the Bucs to break. Hence, the Buccaneers will win in this NFL match.

Chargers vs Broncos

SoFi Stadium will stage the Chargers vs. Broncos NFL clash on September 21, 2025. This NFL week 3 match will start at 04:05 p.m. ET.

Prediction

The Los Angeles Chargers arrive with an excellent opening, having won both fixtures and remaining undefeated. Conversely, the Broncos had an average opening with a 1-1 record and a reasonable away record. Regarding offense, quarterback Justin Herbert has been efficient and dynamic, ranking high in PFF grade, air yards, and success rate. Their defense is also equally impressive as their offense. Additionally, they have a home advantage with a strong home record. Consequently, this match will be a tough contest for the Broncos. But still, the Denver Broncos lead the head-to-head stats and have a rookie quarterback, Bo Nix, who looks promising. The Chargers appear stronger as a team against the Broncos, particularly with their strong offensive start and solid defensive play. Even though the Broncos’ offensive line and head-to-head records are potential factors, the Chargers’ overall form intimidates them. Expect the Chargers to win using the home advantage.

Bears vs Cowboys

The Chicago Bears and the Dallas Cowboys will face each other in the upcoming NFL Week 3 fixtures. This match will be played at Soldier Field on September 21, 2025, at 04:25 p.m. ET.

Prediction

Despite some initial struggles in the defense, the Cowboys’ attacking form is top-tier. Notably, one of the league’s best quarterbacks, Dak Prescott, backs the team’s scoring side. The squad also leads the league in third-down conversions. Dallas strongly receives support from CeeDee Lamb and George Pickens’s partnership in tandem. Moreover, the running back Javonte Williams has impressed with 151 rushing yards in the first two games. Conversely, the Bears seem to be having difficulties with their defensive side. They have allowed 79 points in the first two weeks of matches, which is significantly concerning. Their defensive struggles seem to recur as they gave up 52 points and 8.8 yards per play to the Lions. While both teams have injury lists, the Bears’ injury is more crippling to the team. Considering the contradictory nature of both teams, it is evident that the Cowboys will secure a win against the Bears.

49ers vs Cardinals

The San Francisco 49ers and the Arizona Cardinals will play against each other on September 21, 2025. This game will begin at 04:25 p.m. at Levi’s Stadium.

Prediction

The 49ers include great offensive talents like Christian McCaffrey, George Kittle, Deebo Samuel, and the newly added Ricky Pearsall. Driven by Kyle Shanahan’s strategic vision, the 49ers squad displays superiority in defense and offense. But their defense is weaker compared to their attacking force. They often struggle to face opposing quarterbacks. But their consistent offense and home advantage give them a slight edge. Conversely, the Cardinals primarily rely on a rushing attack, which was at its prime in the 2024 season. They have a solid run game with players like James Conner and Kyler Murray. But their defense is said to be the weakest in the league lately. They previously ranked as the lowest-graded defense and showed difficulties both in the run and pass. Considering the Cardinals’ persisting struggles and the 49ers’ offensive threats, the 49ers are assured to win in this NFL clash.