The NFL 2025-26 Week 4 Story Begins – A Tactical Preview and Prediction

The previous NFL week 3 was thunderous, with several teams scoring beyond the average threshold. Last Sunday’s showdown was an intense, action-packed game that gave us the textbook National Football League glory. After a long day, fans had a worthy showdown where each minute counted. Notably, there were 9 stunning non-offensive touchdowns. Those brought back the peak NFL lore we had in the early 2010s. So, the thrill, excitement, and intrigue factors are back again in the NFL 2025-26. For the upcoming NFL week 4, we have furious matchups made in heaven, like the Buccaneers vs. the Eagles, etc. After all, the league matches are getting more and more intense as each matchday goes by. You should not miss the Super Bowl pursuit ahead. So, stay tuned with us to get regular NFL predictions and game previews.

What Happened in 2025 NFL Week 3 – A Quick Recap of the Highlights

The spotlight highlights several exciting matchups and standout performances in the 2025 NFL week 3. The Detroit Lions delivered a dominant triumph against the Ravens. Their win came with Jared Goff and Montgomery’s outstanding offensive talent. Their defense was also notable, sacking Ravens’ Lamar Jackson seven times. Surprisingly, the Packers received a defeat from the Browns, owing to Cleveland’s robust defense and Andre Szmyt. Andre Szmyt scored the game-winning 55-yard goal. Moreover, the Seattle Seahawks dismantled New Orleans’ squad. The thrilling 95-yard punt return touchdown was the match’s highlight. The Kansas City Chiefs had a resurgence in week 3, beating the Giants by a significant score difference. After a poor start to the season, they defeated the New York Giants by 22-9. Above all, the Minnesota Vikings delivered a jaw-dropping performance of scoring 48 points, which is the headline. Their outstanding defense suffocated the Bengals. Get back-to-back American football updates.

NFL Week 4 Picks – A Detailed Prediction

Every American football fan eagerly waits for the Week 4 NFL prediction to drop. Key matchups like Cardinals vs. Seahawks, Buccaneers vs. Eagles, and Bills vs. Saints will highlight contrasting styles. Moreover, teams will look to build momentum and assert dominance as each matchday goes by. Here, we have provided previews and predictions for every upcoming NFL Week 4 match in detail. This includes previous match breakdowns, head-to-head considerations, and so on. Take a look at them and pick your side. If you want more sports predictions, visit Bettingremier.

Arizona Cardinals vs Seattle Seahawks

The Arizona Cardinals will play the Seattle Seahawks on September 25, 2025. This NFL week 4 match will occur at State Farm Stadium at 08:15 a.m. ET.

Predictions

The Seahawks boast a stunning defensive team. Their defense ranks second in the league, allowing only 15.7 points per game. Additionally, their run defense is worth mentioning, with 3.2 yards allowed per carry, and is ranked third in the NFL. Seattle also leads the league in interceptions and turnovers. They had five interceptions in the first three weeks. On the other hand, the Cardinals’ attacking play has struggled. They have failed to score more than 20 points in either of the games this season. The Cardinals have already struggled against the Seahawks in previous matches. They had difficulties with a limited run game, and their quarterback, Kyle Murray, got sacked five times. Regarding injury lists, the Cardinals had their secondary facing injury concerns. Lastly, the Seahawks had also dominated the rivalry with superior head-to-head statistics. Therefore, this time, the Seahawks have the upper hand in winning against the Cardinals.

Atlanta Falcons vs Washington Commanders

Get ready to watch the intense matchup between the Atlanta Falcons and the Washington Commanders on September 28, 2025. This NFL match will be hosted at Mercedes-Benz Stadium at 01:00 p.m. ET.

Prediction

The Washington Commanders are blessed with a winning prospect this time. Based on their recent performance, the Commanders show significant defensive strength, exhibiting robust play. They rank at respectable spots in several defensive categories. But they have issues with injury lists. This is particularly severe in secondary, posing a significant challenge. Especially, quarterback Jayden Daniels’ availability is still uncertain due to a knee sprain. However, Marcus Martiota comes in aid as a replacement; he performed well in week 3. Conversely, the Falcons’ quarterback and running game go hand in hand. Bijan Robinson exhibits a good attacking line, but their defensive line and pass rush struggle. Yet, the offensive coordinator, Zac Robinson’s move to the sideline in week 4, might give a slight tactical shift. Lastly, the Commanders have a favorable head-to-head record as they have won the last seven games against the Falcons. It provides the Commanders a winning chance. 

Houston Texans vs Tennessee Titans

The Houston Texans and Tennessee Titans will compete in the upcoming NFL 2025-26 matchup. Fans await this game at NRG Stadium on September 28, 2025, at 01:00 p.m. ET.

Prediction

The Texans are predicted to win based on recent performances, statistics, and the team’s technical preview. Both Titans and Texans have similar, underwhelming records, 0- 3 this season, and they have struggled offensively. The Houston Texans scored just 38 points through three games, which is the second-lowest in the league. Similarly, the Titans have the lowest total yards, only 192.5 per game. Another concern is that the Titans’ quarterback starter, Will Levis, is out for this season due to his shoulder surgery. For the quarterback substitution, Cam Ward replaces him. Although Ward performs better, but the offensive line has allowed 15 sacks. Likewise, the Texans suffer from a poor attacking front, but their defense is slightly better than the Titans. The Texans slightly rank better than the Titans in overall defense. Given the Texans’ relative dominance, the Houston Texans will beat the Tennessee Titans in this NFL match.

Tampa Bay Buccaneers vs Philadelphia Eagles

The Tampa Bay Buccaneers and the Philadelphia Eagles are clashing with each other on September 28, 2025. This NFL showdown will occur at Raymond James Stadium at 01:00 p.m. ET.

Prediction

Given their historical trends and current form, the Philadelphia Eagles are favored to win this upcoming NFL matchup. Even though the Tampa Bay Rays have a home advantage, the Eagles are the current defending Super Bowl champions. They have an unshakable record this season so far. The Jalen Hurts and Saquon Barkley duo leads the offensive threat. Moreover, the Eagles overcame a large deficit with a strong second-half comeback this season. On the other hand, the Buccaneers are starting this season with a 3-0 record, an unbeatable status. They have also recently succeeded against the Eagles, winning their last two head-to-head encounters. Historically, they have an advantage at home. However, the Tampa Bay squad suffers from injury lists. It includes key offensive linemen and wide receiver Mike Evans. This has led to much pressure on the team’s offensive side. Hence, the Eagles are assured of winning this NFL match.

Buffalo Bills vs New Orleans Saints

The Buffalo Bills and the New Orleans Saints will clash at Highmark Stadium on September 28, 2025. This NFL showdown will begin at 01:00 p.m. ET.

Prediction

The Buffalo Bills enter the NFL Week 4 matches list undefeated and with a formidable offensive balance. They also show a top-tier defense. Regarding the passing and rushing attacks, the Bills have Josh Allen. Josh Allen is a top MVP with three touchdowns and has managed the game efficiently. Additionally, James Cook’s ground gains provide stability. Their overall squad depth will allow them to take control of the game to relieve pressure and avoid getting drained. In contrast, the Saints squad had a terrible season opener and continues to struggle with mistakes. Despite occasional hopes from Spencer Rattler, they lack offensive explosiveness. Their attack has averaged only 4.4 yards per play and four plays of 20+ yards so far. They often make discipline errors, which cannot be afforded, showing their lethargic defensive side. Considering the strengths and weaknesses, the Buffalo Bills are predicted to win in this NFL clash.

San Francisco 49ers vs Jacksonville Jaguars

The San Francisco 49ers and the Jacksonville Jaguars will clash in the NFL Week 4 on September 28, 2025. This clash will occur at Levi’s Stadium at 05:05 p.m. ET.

Prediction

The 49ers team enters the game having won its first three matches this season and has a perfect record. Mac Jones and Christian McCaffrey will deploy effective play-action and a balanced approach. Their offensive line protection will allow Jones to find emerging receivers like Ricky Pearsall. Moreover, their run defense remains strong despite Nick Bosa’s absence in week 4. On the other hand, the Jaguars had a mixed opening with a 2-1 record and excelled in generating turnovers. They lead the league in takeaways and interceptions after three games. Trevor Lawrence’s dynamic contribution and full field use allow them to sustain. However, the 49ers get a home advantage this time at Levi’s Stadium. We can expect a disciplined play from the 49ers, hinting at a decisive outcome. Their ability to close games, coupled with the home advantage, indicates a narrow edge over Jacksonville in this NFL clash.

Los Angeles Rams vs Indianapolis Colts

Prepare for the Los Angeles Rams vs the Indianapolis Colts NFL match on September 28, 2025. This match will start at 05:05 p.m. ET at SoFi Stadium.

Prediction

The Los Angeles Rams welcome the unbeatable Indianapolis Colts in a promising Week 4 NFL match. The Colts enter this match undefeated, having won all three of their matches this 2025-26 campaign. They ranked second in this league with 34.3 points per game. Their quarterback has a strong output rate, has avoided turnovers, and has distributed the ball effectively. In terms of run defense, it has restricted damage and positively impacted turnovers. Conversely, the Rams counter with a dynamic receiver, Puka Nacua, and a versatile running back, Kyren Williams. Matthew Stafford’s veteran poise and creative play-calling further strengthen the team. They also have a strong defensive side, leading the league in imposing sacks. This shows their ability to disrupt opponents’ progression. However, the Colts have the home advantage. The match should be a tightly contested one with the Colts having the slight edge to beat out the Rams.

Kansas City Chiefs vs Baltimore Ravens

The Kansas City Chiefs will face the Baltimore Ravens on September 28, 2025, at 05:24 a.m. ET. Expect this match to take place at Arrowhead Stadium.

Prediction

The Kansas City Chiefs and the Baltimore Ravens are two powerhouse teams looking to stabilize their squads after slow starts. The Ravens, led by Lamar Jackson’s riveting passing skills, rank first in the NFL in points. But they are grappling with defensive weakness. Particularly, they struggle with poor tackling skills and a susceptibility to yards after contact. The Chiefs, in contrast, have been inconsistent but quickly rebounded. But still, they have defensive concerns and struggled to generate turnovers. Although they have the home crowd support this time, the Ravens’ dynamic defense will likely challenge the Chiefs’ secondary. The Baltimore Ravens have multifaceted playmaking skills and possession skills. This match will be closely contested. However, the Baltimore Ravens are expected to beat the Kansas City Chiefs due to their superior form and rounded support.

Dallas Cowboys vs Green Bay Packers

The Dallas Cowboys and the Green Bay Packers will clash in the upcoming NFL clash on September 28, 2025. This NFL Week 3 clash takes place at AT&T Stadium at 08:20 p.m. ET.

Prediction

The Week 4 Dallas Cowboys versus Green Bay Packers game looks intriguing. First, the Cowboys lose star receiver CeeDee Lamb due to a high-ankle sprain. As a result, it weakened their previously impressive aerial attack. Dak Prescott will rely more on secondary options like George Pickens and Jake Ferguson. Meanwhile, the running game looks impressive. On the other hand, the Green Bay Packers struggle with inconsistency. They recently had a narrow defeat against the Cleveland Browns. However, they rank high in defense, allowing only 14.7 points per game. Moreover, Jordan Love’s passing has been steady, but he needs to improve his scoring efficiency. The clash hinges on the Packers applying pressure while countering Dallas’s balanced offense. Dallas must overcome key losses to maintain home-field advantage. This matchup promises intensity on both sides. However, the Dallas Cowboys have the chance to beat the Green Bay Packers at home.

Miami Dolphins vs New York Jets

Prepare for the Miami Dolphins vs the New York Jets match at Hard Rock Stadium on September 29, 2025. This match will start at 07:15 p.m. ET.

Prediction

The Miami Dolphins and the New York Jets are searching for their first win as they both had a poor opening. Coached by Mike McDaniel, the Dolphins had shown some promising moments against giants like the Bills. Yet, they underwhelm defensively, allowing more than 31 points per game. Tua Tagovailoa drives the Dolphins in the attacking front with impactful plays, but they also risk turnovers. Additionally, De’Von Achane adds explosiveness in the running game. Conversely, the Jets displayed grit with a near comeback against the Buccaneers. However, they remain inconsistent on offense and defense. Quarterbacks Zach Wilson or Anthony Richardson must protect the ball well against Miami’s aggressive defense. This rivalry is expected to be close, with the Dolphins squad expected to dominate for most of the time. Ultimately, the Dolphins will win due to home-field advantage.