Your longing is over now. The NFL preseason just said goodbye last week, paving the way for the upcoming NFL regular season of 2025-26. If you are mad about the NFL, get all the major updates here. The opening ceremony just commenced brightly last Thursday night with an electrifying NFC East Showdown. The defending Super Bowl champions, Philadelphia Eagles, hosted Dallas Cowboys, setting the right tone for the NFL Regular Season 2025-26. But this was just the beginning of what’s yet to come, as this week poses numerous narratives among legendary rivals. This weekend has multiple storylines, from the Chiefs facing the Chargers to the anticipated rookie debuts of J.J.McCarthy. Additionally, fans contemplate the offseason trades, such as George Pickens joining the Cowboys and his potential contribution to the team. Get ready for an exhilarating NFL showdown this weekend and keep in touch with our American football predictions.
NFL Regular Season 2025 – Week 1 Fixtures
Philadelphia Eagles vs Dallas Cowboys
The Philadelphia Eagles and the Dallas Cowboys clash in the upcoming NFL regular season opener on September 04, 2025. This match will be at the Lincoln Financial Field at 08:20 p.m. ET.
Standings
The Philadelphia Eagles is in the 2nd spot in the NFC East division.
The Dallas Cowboys team is in the 3rd spot in the NFC East table.
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Predictions
The defending Super Bowl champions, the Philadelphia Eagles, enter this game with dominant momentum gained from the previous season. They beat the Cowboys twice last season, outscoring them 75-13. The Eagles’ offense, led by Jalen Hurts, continues to loom with an attacking threat. They have an effective passing and elite rushing ability, which is the result of dynamic wide receivers like A.J. Brown. Additionally, they have a formidable protective wall, despite Darius Slay’s loss.
In contrast, the Cowboys are put to the test without their star linebacker Micah Parsons, as the Green Bay Packers took him away. This is a heavy loss to the team, weakening their defensive backbone. In the offensive unit, quarterback Dak Prescott has returned, but they must adjust to roster changes. While Dallas is motivated to avenge the previous season’s loss, their weak defense prevents it from doing so. Therefore, the Eagles are expected to conquer.
Kansas City Chiefs vs Los Angeles Chargers
The Kansas City Chiefs is last in the AFC West with a 4th spot.
The Los Angeles Chargers team secured the 3rd spot in the AFC West standings.
Standings
Prepare to enjoy the Chiefs vs Giants clash on September 05, 2025. This NFL battle will take place at Corinthians Arena at 08:00 p.m. ET.
Predictions
The Chiefs had a worst preseason with a 0-3 record, particularly struggling on defense against the run. They have allowed over 500 rushing yards across three games. It singlehandedly shows how helpless the team is in terms of defense. Nonetheless, Patrick Mahomes and the starting offense showed signs of confidence. Moreover, the offensive line features new starters like Josh Simmons. Simmons impressed in preseason by steadying pass protection. Despite seeing losses in the preseason, the Chiefs’ offense is solid and determined.
The Chargers had a mixed preseason with a decent defensive side. They challenged opponents’ offensive side occasionally with its pass rushers. On attacking unit, the Chargers showed flashes of efficiency. Overall, the team’s defense decent enough to challenge Chiefs. Based on the preseason performances, Kansas City Chiefs have a way more chance of winning. If you like more sports predictions and updates, follow Bettingpremier.
Miami Dolphins vs Indianapolis Colts
The Miami Dolphins are eager to face the Indianapolis Colts in the upcoming NFL 2025-26 regular season on September 07, 2025. This match will occur at 01:00 p.m. ET at the Colts’ home, Lucas Oil Stadium.
Standings
The Miami Dolphins rule the AFC East with the No. 1 position.
The Indianapolis Colts are in the 3rd spot in the AFC South division.
Predictions
Both the Miami Dolphins and Indianapolis Colts enter this 2025 season with an intriguing but mixed recent form. The Dolphins are safe in the healthy trade, quarterback Tua Tagovailoa, whose presence will significantly impact Miami’s offense. Their offensive side is filled with explosive attackers like De’Von Achane, Tyreek Hill, and Jaylen Waddle. The team aims to refine its attacking potential, which went weak last year. However, they have a concerning defensive side that raises questions about their ability to restrict opposition.
Meanwhile, the Colts arrives with Daniel Jones as quarterback. With offensive strengths like Michael Pittman Jr. and Tyler Warren, their offense shows hope. But it faces challenges from an uncertain offensive line. When looking at their defensive unit, their struggle in the preseason is evident. Even though the Colts have several defensive playmakers, their overall defensive consistency remains unreliable. Therefore, the Dolphins are blessed with a winning prospect.
New York Giants vs Washington Commanders
The New York Giants will face the Washington Commanders on the upcoming NFL match taking place at the Northwest Stadium. This match is scheduled on September 07, 2025 at 01:00 p.m. ET.
Standings
The New York Giants is standing at 1st rank in the NFC East table.
The Washington Commanders is ranked at 4th position in the NFC East.
Predictions
The New York Giants had an outstanding preseason with an undefeated status. They dominated the Bills, Jets, and Patriots. This showcases their effective attacking side led by quarterbacks. Jaxson Dart showed true grit in the field, distributing the ball effectively to weapons like Beaux Collins. The rushing attack found rhythm through multiple backs. Moreover, their defense looked resilient, limiting quality players and supporting well-rounded team effort.
On the other hand, the Commanders struggled in preseason with numerous losses. This includes a 48-18 loss to the Patriots. Their quarterback Josh Johnson implies consistency with multiple interceptions. In addition, their offense struggled to find a form. Although they had a strong previous season, their preseason form has raised several questions. They lack offensive cohesion and defensive depth. Therefore, the Giants appear primed to break the Commanders.
Atlanta Falcons vs Tampa Bay Buccaneers
Prepare to enjoy the Atlanta Falcons vs the Tampa Bay Buccaneers in the upcoming NFL clash. This match will occur at the Mercedes-Benz Stadium on September 07, 2025, at 01:00 p.m. ET.
Standings
The Atlanta Falcons is ranked lower at the 4th spot in the NFC South division.
The Tampa Bay Buccaneers is at the 1st spot in the NFC South division.
Predictions
The Tampa Bay Buccaneers enter the game with a strong base of experienced players led by quarterback Baker Mayfield. Their offense shows sharpness and cohesion, with Mike Evans and Chris Godwin’s effective contributions. Similarly, their defense is bolstered by a solid pass rush and strong secondary presence from Antoine Winfield Jr. Overall, their form is built to overwhelm opposing quarterbacks. Ultimately, Tampa Bay’s stability gives an obvious edge for them.
The Falcons have put Elijah Wilkinson as their starting right tackle for the upcoming game. Their rookie edge rusher, Jalon Walker, adds more defensive solidity to the team. However, key injuries like wide receiver Darnell Mooney still raise some concerns. The Falcons’ offense is skilled but lacks adequate experience. They were inconsistent throughout the preseason. Moreover, their defense needs more time to cultivate cohesion and form. Hence, the Buccaneers will stand above.
Cleveland Browns vs Cincinnati Bengals
The Cleveland Browns and Cincinnati Bengals feature in the upcoming NFL clash on September 07, 2025. This match will begin at 04:05 p.m. ET at the Huntington Bank Field.
Standings
The Cleveland Browns is in 2nd position in the AFC North table.
The Cincinnati Bengals is in the 4th place in the AFC North standings.
Predictions
The preseason and offseason outcomes build an exciting narrative around the upcoming clash between the Bengals and the Browns. In the last season, the Bengals had a disappointing finish. But they have refocused with the quarterback Joe Burrow, displaying sharpness and fitness. Cincinnati’s passing game looks capable of challenging Cleveland with elite receivers Ja’Marr Chase and Tee Higgins. Yet, their offense remains a concern. Against a promising squad, the Bengals are at risk with a weaker overall offense.
Conversely, the Browns had Joe Flacco as quarterback for stability and are cautious with rookies Dillon Gabriel and Shedeur Sanders. Flacco’s experience, combined with playmakers Jerry Jeudy and David Njoku, could stretch the Bengals’ defense. Especially, the Bengals’ defense will stretch more if their pass rush shows inconsistency. As a result, the Cleveland Browns will win this NFL clash. Click here to get betting insights.
San Francisco 49ers vs Seattle Seahawks
The San Francisco 49ers will fiercely face the Seattle Seahawks in the upcoming NFL match on September 07, 2025. This match will be at 04:05 p.m. ET, occurring at Lumen Field.
Standings
The San Francisco 49ers secured the 2nd spot in the NFC West division.
The Seattle Seahawks team is ranked in 4th spot in the NFC West standings.
Predictions
The San Francisco 49ers finished with a solid 2-1 record, with a competitive win against the Chargers. It highlights their offensive and defensive balance. The team has a solid offense with Kyle Shanahan and key players like Christian McCaffrey, George Kittle, and Brock Purdy. Defensively, Robert Saleh leads the team returning as coordinator, making it more intense and determined. The run and pass rush is especially heightened, which instills confidence in the upcoming regular season.
The Seahawks are in transition from the preseason. Sam Darnold, the new starting quarterback, is adjusting to Mike Macdonald’s coaching. Their preseason record was inconsistent, with attacking inefficiency due to injured lines and difficulties maintaining the rhythm. But still, Seattle’s defensive backfield shows hope in pass coverage even though its offense could not fully capitalize. Based on preseason performances, the 49ers have the luck to shine this time.
Denver Broncos vs Tennessee Titans
The Denver Broncos and the Tennessee Titans will clash in the NFL 2025-26 season openers on September 07, 2025. This regular-season clash takes place at Empower Field, and the teams will root for Super Bowl LX. This match will begin at 01:35 a.m. ET.
Standings
The Tennessee Titans stand in 1st place in the AFC South standings.
The Denver Broncos is at the 1st rank in the AFC West Standings.
Predictions
The Broncos had an undefeated preseason run, securing a solid 28-19 closing game against the New Orleans squad. It was possible for the Denvers with the quarterback Bo Nix, who finished 10-for-14 with 198 yards. Their offensive side is improving every week, as seen in both pass protection and red zone effectiveness. In terms of defense, they force key turnovers by exploiting opponents’ careless errors, eventually transforming them into points.
Conversely, the Titans had just finished the preseason at 2-1, led by Cam Ward. While Ward shows occasional flashes of promise, he remains unproven and is still working to find consistency. The Tennessee squad had decent wins like 23-20 over Atlanta and a solid outing against Minnesota. Their offensive line is still in progress which might become weak against Denver’s relentless offensive pressure. As a result, Denver Broncos will hoist the triumph flag at their home.
Green Bay Packers vs Detroit Lions
The Green Bay Packers will face the Detroit Lions on September 07, 2025. This NFL regular-season clash will be a home match for the Packers at Lambeau Field at 04:25 p.m. ET.
Standings
The Green Bay Packers have secured the 2nd spot in the NFC North Rankings.
The Detroit Lions got 4th place in the NFC North standings.
Predictions
The Packers closed the preseason with a solid 2-1 record, boasting a two-game winning streak. They also show improvements on both sides of the ball. Jordan Love led the offensive side and effectively created cohesion with rookies and new backfield addition Josh Jacobs. On the defensive side, new star player Micah Parsons and safety Xavier McKinney dominated the field multiple times.
Conversely, the Lions endured a harsh preseason. It included a heavy defeat against the Chargers, highlighting the squad’s persisting vulnerabilities. While Jared Goff, Amon-Ra St. Brown, and Jahmyr Gibbs have proven strengths, their defense broke down against quality opponents. The team gave up too many points in the division in the preseason. Despite having a solid stack of offensive strength, their team looks out of sync. Particularly, the defense is too weak. Ultimately, the Green Bay Packers can win this NFL opening week match.
Baltimore Ravens vs Buffalo Bills
Get ready to cheer for the NFL game between the Baltimore Ravens and the Buffalo Bills on September 07, 2025. The battle takes place at Highmark Stadium at 08:20 p.m. ET.
Standings
The Baltimore Ravens are at the 1st rank in the AFC North division.
The Buffalo Bills is standing at the 3rd spot in the AFC East rankings.
Predictions
The Baltimore Ravens recently performed well with an outstanding defense and offense. They exhibited sharp movements and great finishing. So, Raven’s side is stronger in comparison. With Lamar Jackson as a strong quarterback, the team connects Rashod Bateman and Isaiah Likely, forming good cohesion. Particularly, Derrick Henry acts as the main force in the running game. Moreover, their defenses are resilient, which forces turnovers and contains opponents.
The Bills, conversely, are fresh off a competitive playoff clash against the Ravens in early 2025. They also showed mixed results in the preseason, but it has retained capable offensive power. On the team, Josh Allen displayed his dual-threat abilities with effective passing and rushing. Weapons like Stefon Diggs and the running backs supported him. However, the Buffalo Bills team faced some defensive challenges. They struggle to keep the form intact. Considering these factors, Baltimore has the chance to rule out the Bills.