NFL 2025-26 Week 5: A Regular Season Preview & Prediction

The National Football League currently features silent wars among teams, as it is the regular season. Teams are rushing to make an impression and earn an initial ranking spot. Given the NFL regular season’s contention, teams are serious as if it’s a Super Bowl contention. The NFL regular season, week 5, features key fixtures that resemble and recreate the Super Bowl showdown. Fans are expecting these matches with a great emotional investment. Additionally, several exciting moments took place before the matchday. Rookie quarterbacks, injury lists, sacking, and other riveting moments defined matchday 4. Now, the attention has turned towards NFL matchday 4. Losers await revenge and winners aim to reassert their dominance. Let’s see who flips the table and who submits. Until then, read our detailed NFL American football game analysis and predictions. If you like it and want more, click here for regular American football updates.

NFL 2025-26 Week 4 – What Happened?

Thrilling 40-40 Draw

The Green Bay Packers and Dallas Cowboys played an interesting match that day. It was an eye-for-an-eye match, with each team scoring 40 goals, but the game ended in a draw. The Packers had an initial momentum with Jordan Love and Romeo Doubs’ teamwork. However, after their dual touchdowns, the momentum shifted. Cowboys’ Juanyeh Thomas converted Green-Bay’s progression and scored two. After that, the Cowboys had a great time neutralizing. They soon reached a 16-13 lead before the halftime break. The second half mostly lingered on a back-and-forth dominance and power imbalance. Notably, Dak Prescott shone, completing 78% of his passes for 319 yards and three touchdowns. Green Bay’s Jordan Love also had a strong performance with 337 yards and three touchdowns. Just seconds before overtime’s end, Brandon McManus tied the match with his 34-yard field goal.

Significant Upsets

NFL Rookie quarterback Jaxson Dart significantly contributed to the New York Giants’ astounding win against the unbeaten Los Angeles Chargers. His 15-yard rushing touchdown demonstrated his MVP potential. Moreover, he is the first quarterback since Mahomes to lead an 80+ yard touchdown on the opening possession. Likewise, the Jacksonville Jaguars beat the 49ers with a 26-21 scoreboard. Additionally, the Los Angeles Rams broke the Indianapolis Colts’ undefeated streak with a 27-20 win. The Rams sealed the victory with an 88-yard touchdown pass from Matthew Stafford to Tutu Atwell. Dramatically, the Chicago Bears secured a single-score-difference win against the Las Vegas Raiders. They stopped the game-winning field goal attempt at the final minute. Lastly, the Pittsburgh Steelers had their 2025 first international NFL win. They defeated the Minnesota Vikings by 24-21 in Dublin, Ireland.

Notable Individual Performances and Team Moments

Patrick Mahomes made history at the matchday 5 NFL game. He became the youngest quarterback to throw 250 career touchdowns in NFL history. The Kansas City quarterback scored his historic 250th touchdown throw in a 37-20 win against the Baltimore Ravens. Matthew Stafford threw an 88-yard touchdown pass to Tutu Atwell in the Rams’ comeback match. It was the longest of Stafford’s professional career. Moreover, the Houston Texans won their first season, defeating the Tennessee Titans, who fell to 0-4. Finally, the cornerback, Marcus Jones, returned an 87-yard punt for a touchdown. He sparked the Patriots’ 42-13 dominant win over the Panthers.

NFL Picks for the Upcoming NFL Week 5

Several exciting matches this week feature top teams clashing. These matches evoke questions about teams’ comebacks, rookies’ future contributions, and transfer decisions. The upcoming NFL Week 5 will answer all the questions. For that, we gave the NFL predictions below. Pick your side wisely. If you like our commentaries and sports predictions, you can find more on our site.  Click here to get more sports predictions and sensational updates.

Jets vs Cowboys

The New York Jets will face the Dallas Cowboys on October 5, 2025, at 01:00 p.m. ET. This NFL regular season will occur at MetLife Stadium, giving the Jets a home venue.

Preview

After a dramatic draw against the Green Bay Packers, the Cowboys team enters this game. Their attacking force is powerful, especially with Dak Prescott’s performance. But their defense has struggled recently, particularly against the opponent’s run game. Wide receiver CeeDee Lamb’s absence and offensive line issues further weaken their defensive side. Conversely, the New York Jets enter this match after losing to the Miami Dolphins. Previously, they committed three turnovers and numerous penalties. However, quarterback Justin Fields gained around 400 yards in total. It included the 197 rushing yards. His mobility and Dallas’s run defense struggles could be a key factor. However, the Dallas Cowboys’ new head coach, Brian Schottenheimer, is in his first season. Moreover, their squad has playoff-potent players with a good league history. Therefore, despite playing away, the Cowboys will win in the upcoming NFL match against the Jets.

Colts vs Raiders

The Indianapolis Colts are set to face off against the Las Vegas Raiders in the upcoming NFL match. This game will happen at Lucas Oil Stadium on October 05, 01:00 p.m. ET.

Preview

The Indianapolis Colts have a better offense and are ranked fourth in attacking play. Their offensive efficiency is greater than their rivals, leading the league in yards per play. Furthermore, they are exceptionally skilled at protecting the ball. They also force turnovers effectively. As a result, they have a positive turnover margin, whereas the Raiders have a negative one. This places them in a higher position to gain and sustain control over their opportunities. On the other hand, the Raiders’ quarterback is prone to interceptions and leads the league. At the same time, the Colts give up only a few sacks. Previously, the Raiders had shown a strong run defense. But compared to the Colts’ running game, they might struggle this time. In addition, the Raiders miss their starting left tackle, Kolton Miller, due to the injury list. Therefore, the Colts will win decisively.

Panthers vs Dolphins

The Miami Dolphins meet the Carolina Panthers at Bank of America Stadium for the NFL regular season. Carolina hosts Sunday, October 05, 2025, 01:00 p.m. ET in North Carolina.

Preview

The Miami Dolphins arrive with a quarterback play advantage, but they miss their top offensive powerhouse, Tyreek Hill. This loss heavily impacts the team and its overall offensive efficiency. Even with Tyreek Hill, the team’s performance was average this season. Moreover, their running defense is weak, giving up the third-most rushing yards. Conversely, the Panthers’ attacking side has also been average lately. But they might find chances using Miami’s weak run defense. This is particularly strong with running back Rico Dowdle’s workload. The passing defense is the Carolina Panthers’ biggest strength currently. They rank among the best in the number of passes allowed. This could help them nullify Miami’s passing attack. Ultimately, this game will be a low-scoring match given each team’s offensive struggles. However, the Carolina Panthers get a home advantage this time. Coupled with their better defense, the Panthers appear stronger. Hence, they will win over the Dolphins.

Eagles vs Broncos

The Denver Broncos test the Philadelphia Eagles during the NFL regular season at Lincoln Financial Field. Philadelphia hosts Sunday, October 05, 2025, 01:00 p.m. ET in Pennsylvania.

Preview

The Denver Broncos seem to have a great defensive advantage. They have a good position in total, rush, and pass defense. This formidable defensive formation will significantly challenge the Eagles’ attacking side. Such a strong and well-rounded defense is too elite for the Philadelphia Eagles. However, the Philadelphia Eagles hold key advantages that could drive the team to victory. In particular, they have Jalen Hurts, the best quarterback in the league. He has consistently performed across all the games he has played. Their offense has been excellent, especially in the red zone. This red zone effectiveness will help them tackle the Broncos’ solid defense. The Eagles also lead among other teams in turnover differential. This will enable them to protect the ball and create takeaways. After all, the Eagles get a home advantage this time. Combined with all the benefits, their home advantage ultimately gives them an edge to win.

Ravens vs Texans

The Houston Texans clash with the Baltimore Ravens in regular-season action at M&T Bank Stadium. Baltimore hosts Sunday, October 05, 2025, 01:00 p.m. ET in Maryland.

Preview

The Baltimore Ravens enter this match with key injury-list players. Their offensive dynamics are heavily advanced against their own efforts. Conversely, the Texans’ defense is among the league’s best in points and yards allowed. Adding to this, the Ravens’ offense solely relies on Lamar Jackson. But Lamar Jackson is reported to have a hamstring issue. Therefore, the Texans hold a technical advantage over the Ravens. Although they have a strong rushing attack, this injury has negatively impacted their offense. Moreover, the Ravens also had defensive vulnerabilities, given their poor outcome in points allowed. Overall, the Baltimore Ravens’ offense and defense are weak, given their current squad conditions. Home advantage is the only comfort they get this time. However, the Texans’ elite defense will easily contain the Ravens. This match will more likely be a close contest. However, the Texans are slightly favored to win in this NFL fixture.

Seahawks vs Buccaneers

The Tampa Bay Buccaneers face the Seattle Seahawks at Lumen Field in an NFL regular-season duel. This match is scheduled on October 05, 2025, 04:05 p.m. ET in Seattle, Washington.

Preview

The Seahawks enter with a solid offense and turnover differential, whereas the Buccaneers have better defense and pass protection. They hold a significant offensive advantage. The Seahawks also excel at turning red zone opportunities into touchdowns. They are among the best scoring teams in the league and excel in passing and rushing. Notably, they are second in the league at turnover differential, indicating their ability to protect the ball and create takeaways. Conversely, the Tampa Bay Buccaneers’ defense is their biggest strength. They allow fewer total yards and passing yards than the Seahawks. Their offensive line is also good at protecting their quarterback. However, their attacking form has been inactive for most of the time. They are unreliable in touchdowns and yards per game. Combined with a poor turnover differential, the Buccaneers are inferior to the Seahawks’ explosive offense. So, the Seattle Seahawks will win this NFL match.

Bengals vs Lions

The Detroit Lions confront the Cincinnati Bengals in regular-season football at Paycor Stadium. This NFL regular-season duel kicks off Sunday, October 05, 2025, at 04:25 p.m. ET in Cincinnati.

Preview

The Lions arrive with a three-game winning streak, including solid passing and rushing performances. Quarterback Jared Goff is in great form, which might challenge the Bengals’ weak defense against the run. The Bengals are also declining, losing their last two games by large margins. Cincinnati mainly suffers from the absence of starting quarterback Joe Burrow. The backup Jake Browning is underwhelming to the squad’s scoring side. Moreover, the Bengals’ defensive struggles are evident in the statistics, particularly against the run. In addition, they rank last in rushing and lead in giveaways. This ultimately puts them at a vulnerable spot, paving the way for the Lions to exploit. However, the Bengals have a home crowd support, which may not be a decisive factor, but will help them sustain. Yet, the Lions’ current strong form and key matchup advantages will help them win this NFL clash.

Chargers vs Commanders

The Washington Commanders take on the Los Angeles Chargers during the NFL regular season at SoFi Stadium. This game begins on Sunday, October 05, at 04:25 p.m. ET.

Preview

The Los Angeles Chargers offense is the league’s best in points and passing yards per game. Notably, Quarterback Justin Herbert is a star player who can consistently score with his elite signal-calling. Their offense is perfectly suited to exploit the Commanders’ unstable pass defense. In contrast, the Washington Commanders are unorganized and are poor at offense in the entire league. Their quarterback, Sam Howell, has been inactive and has experienced more sacks and interceptions. They also have an underwhelming turnover differential. While both teams struggle with turnovers, the Commanders have a better run defense. In summary, the Los Angeles Chargers have a superior offensive production and elite quarterback play. They will also exploit the Commanders’ glaring defensive weaknesses. After all, the Los Angeles Chargers have the home advantage in the upcoming NFL match. Therefore, the Los Angeles Chargers are assured they will win this NFL match.

Bills vs Patriots

The New England Patriots face the Buffalo Bills during the NFL regular season at Highmark Stadium. Buffalo will welcome the Patriots on Sunday, October 05, 2025, at 08:20 p.m. ET.

Preview

The Buffalo Bills are an elite NFL team that thrives on consistent scoring and a solid defensive front. They have an MVL-level quarterback and are great at generating turnovers. The Bills are currently undefeated and playing at a good pace. But still, the New England Patriots are no less than the Bills. They present a challenging defensive wall, particularly against the run. The Patriots also have a stronger pass defense than the Bills’ vulnerabilities. Additionally, Patriots rookie quarterback Drake Maye shows occasional improvements. So, the Buffalo Bills might have to spend some time breaking the Patriots’ defense, particularly against their run-stopping ability. Conversely, the Patriots must quickly force turnovers under the Bills’ occasional lapses. But the Buffalo Bills arrive with a home advantage this time. Despite the Patriots’ recent improvements, the Bills’ overall strength and home advantage will make them the winners.

Jaguars vs Chiefs

The Kansas City Chiefs challenge the Jacksonville Jaguars in regular-season football at EverBank Stadium. Jacksonville hosts on Monday, October 06, 2025, at 08:15 p.m. ET in Florida.

Preview

The Jaguars and the Chiefs have contrasting strengths and weaknesses. While the Kansas City Chiefs have a top MVP, Patrick Mahomes, the Jaguars have several tactical perks. The Jaguars have a strong defensive side, ranking among the NFL’s best. Notably, they lead the league in turnover differential. Their deliberate and controlled defense is a significant factor in this clash. Yet, they will face challenges while containing Chiefs’ elite quarterback Mahomes. The defensive lineman, Chris Jones, further complicates the task. Chris Jones’ return will significantly boost the team’s pass rush. Consequently, the Jaguars might face further difficulties besides their injury lists. Ultimately, the game will linger on the Jaguars’ defense trying to pressure Patrick Mahomes. Above all, the Jaguars’ home-field advantage will make it a close contest; each has their own strength. However, the Kansas City Chiefs will ultimately win over the Jacksonville Jaguars in this NFL match.